Table 2.
Improvements and the number of miRNA–target interactions with different validation methods provided by miRTarBase 8.0
| Features | miRTarBase 7.0 | miRTarBase 8.0 |
|---|---|---|
| Release date | 2017/09/15 | 2019/09/15 |
| Known miRNA entry | miRBase v21 | miRBase v22 |
| Known Gene entry | Entrez 2017 | Entrez 2019 |
| Species | 23 | 32 |
| Curated articles | 8,510 | 11,021 |
| miRNAs | 4,076 | 4,312 |
| Target genes | 23,054 | 23,426 |
| CLIP-seq datasets | 231 | 331 |
| Curated miRNA–target interactions | 422,517 | 479,340 |
| Text-mining technique to prescreen literature | Enhanced NLP | Enhanced NLP+Scoring system |
| Download by validated miRNA–target sites | Yes | Yes |
| Browse by miRNA, gene, and disease | Yes | Yes |
| Regulation of miRNAs | No | Yes |
| Cell-free miRNA expression | No | Yes |
| MTIs Supported by strong experimental evidences | ||
| Number of MTIs validated by ‘Reporter assay’ | 9,489 | 13,922 |
| Number of MTIs validated by ‘Western blot’ | 7,258 | 12,179 |
| Number of MTIs validated by ‘qRT-PCR’ | 8,210 | 13,263 |
| Number of MTIs validated by ‘Reporter assay and Western blot’ | 6,032 | 10,257 |
| Number of MTIs validated by ‘Reporter assay or Western blot’ | 10,581 | 15,710 |