Table 2.
Transport receptors and cargoes
| Vertebrate karyopherins | Saccharomyces cerevisiae karyopherins | Cargoes (selection) vertebrate (V) yeast (Y) |
|---|---|---|
| Imp‐β/Kapβ1 | Kap95 | Classical NLS via Imp‐α; cyclin B1; snurportin1; SRY; PTHrP; CREB, AP‐1, TRF1, Smad3; SREBP‐2; HTLV‐1 Rex, HIV‐1 Tat, HIV‐1 Rev; NF‐YA; adenovirus core protein pVII; aristaless/arx; cJun; H1; HPV16E6; H1; H2A; H2B; H3; H4; rPL23a, rPS7, rPL5, rPL18a, rPL6, rPL4; PP2A (PR65) |
| Kapβ2 (Transportin/Transportin‐2) | Kap104 | (V) PY‐NLS cargoes; PQBP‐1, YBP1, PABP2, EWS, FUS, SAM68, hnRNP M, hnRNP A1, hnRNP A0, hnRNP A2, hnRNP A3, hnRNP D, hnRNP F, JKTP‐1, TAP (NXF1), HuR, HEXIM1, RB15B, Clk3, WBS16, Cyclin T1, TAFII68, CPSF6, HCC1, ETLE; tfg2p non PY‐NLS cargoes: TAFI48; NPM‐ALK, SRP19; H2A; H2B; H3; H4; c‐Jun; rPL23a, rPS7, rPL5; adenovirus core protein pVII; HIV‐1 Rev; HPV16 E6, HPV16 L2, HPV18 L2 (Y) Nab2p; Hrp1p; Tfg2p |
| Importin‐5 (Kapβ3 or RanBP5) | Kap121 (Pse1) | (V) p60TRP;Rag‐2; PGC7/Stella; apolipoprotein A‐I; influenza A PB1‐PA; HPV18 L2; HPV16 L2; CDK5 activator p35; TAFI48, c‐Jun; HIV‐1 Rev; rPL23a, rPS7, rPL5, rPS3a; H2A; H2B; H3; H4 (Y) Aft1p; Asr1p; Egd1p; Nop1p, Nup53p; Pdr1p; Pho4p; Sas2p; Sof1p; Spo12p; Ste12p; Yap1p; Yra1p; secondary pathway for histones, ribosomal proteins, Ho, SRP, TBP |
| Importin‐4 (RanBP4) | Kap123 | (V) Vitamin D receptor, TP2, HIF1‐α, rPS3a (Y) Egd1p; H3 (Hht2p, H4 (Hhf2p); Sas2p; SRP; Rpl25p, Rp10a, Rps1p, Rpl4p, Rpl15p, Rpl16p, Rpl18p,Rpl25p, Rpl41p; secondary pathway for Asr1p, Asf1p, H2A, H2B, Htz1p, Yap1p, Yra1p, TBP |
| Importin‐9 | Kap114 | (V) Hepatocellular carcinoma associated protein, HSP27, rPS3, rPS9, rPL19, rPL18a, rPS7, rPL6, rPL4; c‐Jun; H2A, H2B, H3, H4; aristaless (Arx); PP2A (PR65); (Y) H2A (Hta1p), H2B (Htb1p, Nap1p, TBP (Spt15p); TFIIB Sua7p); rfp1; secondary pathway for Asr1p |
| Importin‐7 | Kap119 (Nmd5) | (V) Proline‐rich homeodomain; EZI; RK‐2, MEK1, Smad3; HIV‐1 integrase; CDK5 activator p35; HIF1‐α; c‐Jun; glucocorticoid receptor;HIV‐1 Rev; rPL23a; rPS7; rPL5; H2A, H2B, H3, H4; Imp‐β/‐7 heterodimer: H1; HIV‐1 integrase, adenovirus core protein pVII; rPL6, rPL4, rPS3a; (Y) Crz1p; Gal4p; Hog1p; Ssa4p; TFIIS (Dst1p), Rpf1p; secondary pathway for histones H3 and H4 |
| Importin‐8 (RanBP8) | Kap108 (Sxm1) | (V) Ago2; Smad4, Smad1; NPM‐ALK; SRP19; (Y) Lhp1p, Pab1p, Rpl16p, Rpl25p, Rpl34p; secondary pathway for Ho, histones H3 and H4 |
| Transportin‐SR (‐SR2/‐3/TNPO3) | Kap111 (Mtr10) | (V) ASF/SF2, SC35, TRA2α, TRA2β; HPV E2, RBM4, ALEX3, BAB71287, BAP1, MLF2, ODF2; dASF, dSC35, d9G8, Rbp1, B52, RSF1; HIV1 IN; (Y) Gbp2p; Hrb1p; Npl3p; tRNAs |
| – | Kap122 (Pdr6p) | (Y) Imports sc‐cargo – Toa1 and Toa2, TFIIA |
| Importin‐13 | – | NF‐YB/NF‐YC; NC2α/NC2β; Myopodin, hUBC9, elF1A Y14‐Mago; glucocorticoid receptor CHRAC‐15/CHRAC‐17, p12/CHRAC‐17; PAX6, Pax3, Crx; Aristaless (Arx); rPL5; histone fold heterodimers |
| CRM1 (Exportin‐1) | CRM1 (Xpo1/Kap124p) | Leu‐rich NES cargoes; HIV genomic RNA; m7G‐ capped UsnRNAs; 40S and 60S pre‐ribosomal subunits via NMD3 adaptor; snurportin1 (SPN1) |
| CAS (Exportin‐2) | Kap109 (Cse1) | Imp‐αs (Y) Kap60/Srp1 |
| Exportin‐4/Bidirectional NTRs | – | Sox‐2, SRY; eIF5A, Smad3 |
| Exportin‐5 | Kap142 (Msn5) | tRNA, eEF1A (via aa‐tRNA); dsRNA‐binding proteins (via dsRNA); pre‐miRNAs; 60S pre‐ribosomal subunits |
| Exportin‐6 | – | Actin‐profilin complexes |
| Exportin‐7 (RanBP16) | – | p50‐RhoGAP, 14‐3‐3‐σ |
| Exportin‐t (Xpo‐t) | Kap127 (Los1) | tRNA |
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