Figure 3.
Update on combined data from studies of molecular mimicry of the reactivity of monoclonal antiviral antibodies with normal mouse tissue (see refs 30, 31). Lower panels document reactivity of several antiviral monoclonal antibodies that react with host tissues or cells. Left panel: antibody to herpes simplex virus 1 GP reacts with β cells of the islets of Langerhans or their product. Center panel shows monoclonal antibodies to measles virus, Japanese encephalitis virus, and coxsackie B4, which react with growth hormone cells of the anterior lobe of the pituitary, hippocampal neurons, and myocardium (ventricle only and not smooth muscle around the vessel). Right panel displays a monoclonal antibody to HIV GP41 that reacts with astrocytes and the specificity control where addition of HIV GP41 peptide to the monoclonal antibody blocks staining (see Yamada et al., ref 33).