Table 2.
Association Between Coagulation Abnormalities or Markers of Thrombosis and Hemostasis and Clinical Outcomes in Patients With COVID-19
| Han et al., 2020 (24) (N = 94) |
Huang et al., 2020 (1) (N = 41) |
Yang et al., 2020 (26) (N = 52) |
Zhou et al., 2020 (20) (N = 191) | Gao et al., 2020 (27) (N = 43) |
Wang et al., 2020 (16) (N = 138) |
Wu et al., 2020 (19) (N = 201) |
Tang et al., 2020 (7) (N = 183) |
Lippi et al., 2020 (22) (N = 1,779) |
Lippi and Favaloro, 2020 (23) (N = 553) |
Lippi et al., 2020 (36) (N = 341) |
|
|---|---|---|---|---|---|---|---|---|---|---|---|
| Platelet count | |||||||||||
| Setting of comparison | ICU vs. non-ICU | Dead vs. alive | Dead vs. alive | ICU vs. non-ICU | Dead vs. alive | Dead vs. alive | |||||
| Outcome, per cubic millimeter | 196 (165–263) vs. 149 (131–263) | 191 (74) vs. 164 (63) | 166 (107–229) vs. 220 (168–271) | 142 (110–202) vs. 165 (125–188) | 162 (111–231) vs. 204 (137–263) | –48 (–57 to –39)∗† | |||||
| D-dimer | |||||||||||
| Setting of comparison | Severe vs. nonsevere | ICU vs. non-ICU | Dead vs. alive | Severe vs. nonsevere | ICU vs. non-ICU | Dead vs. alive | Dead vs. alive | Severe vs. nonsevere | |||
| Outcome, mg/l | 19.1 vs. 2.1 | 2.4 (0.6–14.4) vs. 0.5 (0.3–0.8) | 5.2 (1.5–21.1) vs. 0.6 (0.3–1.0) | 0.5 (0.3–0.9) vs. 0.2 (0.2–0.3) | 0.4 (0.2–13.2) vs. 0.2 (0.1–0.3) | 4.0 (1.0-11.0) vs. 0.5 (0.3–1.2) | 2.1 (0.8–5.3) vs. 0.6 (0.4–1.3) | 3.0 (2.5–3.5)∗ | |||
| Prothrombin time | |||||||||||
| Setting of comparison | Severe vs. nonsevere | ICU vs. non-ICU | Dead vs. alive | Dead vs. alive | Severe vs. nonsevere | ICU vs. non-ICU | Dead vs. alive | Dead vs. alive | |||
| Outcome, s | 12.7 vs. 12.2 | 12.2 (11.2–13.4) vs. 10.7 (9.8–12.1) | 12.9 (2.9) vs. 10.9 (2.7) | 12.1 (11.2–13.7) vs. 11.4 (10.4–12.6) | 11.3 (1.4) vs. 12.0 (1.2) | 13.2 (12.3–14.5) vs. 12.9 (12.3–13.4) | 11.6 (11.1–12.5) vs. 11.8 (11.0–12.5) | 15.5 (14.4–16.3) vs. 13.6 (13.0–14.0) | |||
| Troponin (hs-TnI) | |||||||||||
| Setting of comparison | ICU vs. non-ICU | Dead vs. alive | ICU vs. non-ICU | Severe vs. nonsevere | |||||||
| Outcome, pg/ml | 3.3 (3.0–163.0) vs. 3.5 (0.7–5.4) | 22.2 (5.6–83.1) vs. 3.0 (1.1–5.5) | 11.0 (5.6–26.4) vs. 5.1 (2.1–9.8) | 25.6 (6.8–44.5)∗ | |||||||
COVID-19 = coronavirus disease-2019; DIC = disseminated intravascular coagulation; hs-TnI = high-sensitivity troponin I; other abbreviations as in Table 1.
∗
Mean difference, results from meta-analysis data.
†
Subgroup analysis of 3 studies.