TABLE 1.
Positive rate of rN-based and rS-based ELISAs for detection of IgM and IgG in serum samples of patients at different stages after disease onset
| Daysb | Total no. of serum samples | No. (%) of serum samples positive for antibody by ELISA |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| IgM |
IgG |
IgM and/or IgGa
|
||||||||
| rN-based | rS-based | P | rN-based | rS-based | P | rN-based | rS-based | P | ||
| Total | 214 | 146 (68.2) | 165 (77.1) | 0.039 | 150 (70.1) | 159 (74.3) | 0.332 | 172 (80.4) | 176 (82.2) | 0.620 |
| 0–5 | 22 | 7 (31.8) | 8 (36.4) | 0.750 | 7 (31.8) | 9 (40.9) | 0.531 | 9 (40.9) | 10 (45.5) | 0.761 |
| 6–10 | 38 | 20 (52.6) | 19 (50.0) | 0.818 | 15 (39.5) | 19 (50.0) | 0.356 | 20 (52.6) | 23 (60.5) | 0.488 |
| 11–15 | 54 | 39 (72.2) | 45 (83.3) | 0.165 | 39 (72.2) | 41 (75.9) | 0.661 | 48 (88.9) | 49 (90.7) | 0.750 |
| 16–20 | 55 | 45 (81.8) | 53 (96.4) | 0.014 | 48 (87.3) | 51 (92.7) | 0.340 | 52 (94.5) | 53 (96.4) | 0.647 |
| 21–30 | 32 | 26 (81.3) | 28 (87.5) | 0.491 | 28 (87.5) | 27 (84.4) | 0.719 | 30 (93.8) | 28 (87.5) | 0.391 |
| 31–35 | 6 | 5 (83.3) | 6 (100.0) | 0.296 | 6 (100.0) | 5 (83.3) | 0.296 | 6 (100.0) | 6 (100.0) | NAc |
| >35 | 7 | 4 (57.1) | 6 (85.7) | 0.237 | 7 (100.0) | 7 (100.0) | N/A | 7 (100.0) | 7 (100.0) | NA |
a
IgM and/or IgG, at least a positive result detected by IgM and IgG ELISA.
b
Days, days post-disease onset.
c
NA, not available.