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. 2020 Jun 5;15:33. doi: 10.1186/s13024-020-00385-5

Table 3.

Plasma NfL, cognitive and motor data in PD patients over different timepoints

Group Values Time Trend p value
Baseline Year 1 Year 2
Total PD NfL 16.16 ± 0.62 16.11 ± 1.37 0.2881
MMSE 26.82 ± 0.23 26.58 ± 0.25 26.9 ± 0.25 0.4523
MoCA 25.06 ± 0.29 25.05 ± 0.31 25.17 ± 0.30 0.9324
Motor 21.32 ± 0.76 24.76 ± 0.84 25.96 ± 1.03 < 0.001
TD NfL 15.79 ± 0.83 12.62 ± 0.81 0.1865
MMSE 26.99 ± 0.30 26.88 ± 0.28 27.13 ± 0.29 0.9128
MoCA 25.32 ± 0.39 25.35 ± 0.39 25.42 ± 0.38 0.8401
Motor 20.99 ± 1.19 24.40 ± 1.20 25.46 ± 1.37 < 0.001
PIGD NfL 15.76 ± 0.96 18.39 ± 2.15 0.0474
MMSE 26.55 ± 0.46 26.06 ± 0.54 26.5 ± 0.46 0.4865
MoCA 24.47 ± 0.48 24.38 ± 0.63 24.61 ± 0.54 0.8705
Motor 22.02 ± 1.28 26.17 ± 1.44 26.80 ± 1.77 < 0.001

Abbreviations: PD Parkinson’s Disease; TD Tremor-Dominant; PIGD Postural Instability Gait Disorder; Motor Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) part III scores; MoCA Montreal Cognitive Assessment; NfL Neurofilament light chain protein

Values represent the mean ± SD