Table 2.
Demographic and neuropathological features of definite cases with LB-Syn+
| List of cases | Sex | Age at LP | Age at death | Primary NP diagnosis | Secondary NP diagnosis | McKeith stage | Braak stage |
|---|---|---|---|---|---|---|---|
| Case #1 | F | 79 | 79 | DLB | AD (low) | Neocortical | 6 |
| Case #2 | F | 81 | 81 | DLB | AD (low) | Neocortical | 6 |
| Case #3 | F | 79 | 81 | DLB | AD (intermediate) | Neocortical | 6 |
| Case #4 | M | 77 | 77 | DLB | AD (intermediate) | Neocortical | 6 |
| Case #5 | M | 63 | 65 | DLB | AD (high) | Neocortical | 6 |
| Case #6 | M | 77 | 77 | DLB | AD (intermediate) | Neocortical | 6 |
| Case #7 | F | 81 | 81 | DLB | AD (intermediate) | Neocortical | 6 |
| Case #8 | M | 80 | 80 | DLB | AD (intermediate) | Neocortical | 6 |
| Case #9 | F | 82 | 83 | DLB | AD (intermediate) | Neocortical | 5 |
| Case #10 | M | 71 | 72 | DLB | AD (low) | Neocortical | 5 |
| Case #11 | M | 73 | 73 | DLB | AD (low) | Neocortical | 5 |
| Case #12 | F | 76 | 77 | DLB | AD (intermediate), CAA, subcortical arteriosclerotic encephalopathy | Limbic | 4 |
| Case #13 | M | 73 | 73 | DLB | AD (intermediate), CAA | Limbic | 4 |
| Case #14 | M | 83 | 83 | DLB | AD (intermediate), CAA | Limbic | 4 |
| Case #15a | M | 67 | 67 | sCJD MM1b | DLB | Neocortical | 5 |
| Case #16a | F | 73 | 73 | sCJD VV2b | DLB, AD (intermediate), CAA | Neocortical | 5 |
| Case #17a | F | 75 | 76 | Primary CNS lymphoma | PARTc | Limbic | 4 |
| Case #18a | M | 87 | 87 | Metabolic encephalopathy | AD (low), lacunar stroke | Brainstem | 3 |
| Case #19a | M | 72 | 73 | sCJD VV2b | AD (low) | Brainstem | 2 |
| Case #20a | M | 81 | 81 | sCJD MV2K + 2Cb | AD (low) | Brainstem | 1 |
| Case #21a | F | 65 | 65 | sCJD MM1b | None | Brainstem | 1 |
LP lumbar puncture, NP neuropathologic, DLB dementia with Lewy bodies, AD Alzheimer’s disease, CAA cerebral amyloid angiopathy, CNS central nervous system, sCJD sporadic Creutzfeldt–Jakob disease, PART primary age-related tauopathy
aDementia with incidental LB co-pathology
bsCJD subtypes were defined in accordance with Parchi et al. [47]
cPART was diagnosed according to Crary et al. [18]