. 2020 Aug 5;10(8):e038911. doi: 10.1136/bmjopen-2020-038911

Table 1.

Schedule of activities for the UP study

	Procedure	Screening	Baseline	Week 12	Week 24	Week 36	Week 48	Week 56
Medical history	Consent	X
	Review inclusion/exclusion criteria	X	X
	Demographics	X
	Medical history and physical examination	X
	Height and weight	X					X
	Genetics Sample		X
Medication	Randomisation		X
	Medication supply		X	X	X	X
	Concomitant medication review	X	X	X	X	X	X	X
	Compliance review			X	X	X	X
Clinical assessment/outcome measures	MDS-UPDRS Part 3 ‘OFF’		X				X	X
	MDS-UPDRS Part 3 ‘ON’				X
	MDS-UPDRS Parts 1–4 ‘ON’		X				X	X
	MoCA, MADRS	X					X	X
	PDQ-39		X				X	X
	NMS-QUEST		X				X
Sensor-based analysis	Dynaport Move Monitor +7 days recording	X					X (7 days prior)
Sensor-based analysis	OptoGait/Opals gait assessment ‘OFF’		X				X
MRI	³¹P-MRS		X				X
Safety monitoring	Safety bloods	X	X	X	X	X	X	X
	ECG	X			X
	AE review		X	X	X	X	X	X

AE, adverse event; MADRS, Montgomery-Asberg Depression Rating Scale; MDS-UPDRS, Movement Disorders Society Unified Parkinson’s Disease Rating Scale; MoCA, Montreal Cognitive Assessment; NMS-QUEST, Non-Motor Symptom Questionnaire; PDQ-39, 39-Item Parkinson’s Disease Questionnaire; ³¹P-MRS, ³¹Phosphorus MR spectroscopy.