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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Lancet Neurol. 2020 May 26;19(6):513–521. doi: 10.1016/S1474-4422(20)30137-X

FIGURE 2. Rate of change in Plasma NfL levels as a function of age in mutation carriers and non-carriers: Log-transformed longitudinal data.

FIGURE 2

A. Longitudinal change rates of plasma NfL as a function of age. B. Change rate differences between carriers & non-carriers as a function of age (i.e., the space between the carrier and non-carrier mean values at any given age). Non-carrier rates are set at zero. The rate of NfL increases in PSEN1 E280A mutation carriers began to differ from non-carriers at age 22, 22 years before the carriers’ estimated median age of 44 at MCI onset. Log-transformed data were modeled using Linear Mixed Effects Models (LMEMs), a restricted cubic spline, & Hamiltonian Markov chain Monte Carlo (MCMC) analyses. The shaded areas represent 99% credibility intervals. The underlying modeling procedures used in the generation of these representations of the longitudinal changes rates of plasma NfL are very similar to those used to generate the representations in Figure 1 (cross-sectional plasma NfL between carriers and non-carriers) but the dependent variable (i.e. the rate of change in NfL) of the models was different between the analyses.

Pg/ml= Picograms Per Milliliter