Table 3.
Baseline plasma NfL levels, clinical measures, and demographics in impaired carriers, unimpaired carriers and non-carriers (age above 18 years old)
| Impaired carriers | Unimpaired carriers | Non-carriers | p-value* | |
|---|---|---|---|---|
| N | 154 | 573 | 743 | |
| Age (years) | 50±6 (39 – 73) | 31±9 (18 – 67) | 37±13 (18 – 75) | <0.0001 |
| Male(%) | 68(44.2%) | 257(44.9%) | 327(44.0%) | 0.95 |
| Female(%) | 86(55.8%) | 316(55.1%) | 416(56%) | 0.95 |
| Education (years) | 5.1±3.7 | 7.9±4.4 | 8.6±4.8 | <0.0001 |
| MMSE | 17.61±7.00 | 28.34±2.18 | 28.71±2.39 | <0.0001 |
| CERAD Word List Delayed Recall | 1.84±1.55 | 5.78±2.00 | 6.28±1.82 | <0.0001 |
| NfL (pg/ml) | 41.83±83.41 | 9.07±8.34 | 10.73±26.92 | <0.0001 |
Reported values are means and standard deviation (SD). All p-values are based on the raw measures (without log transformation) and without adjusting for covariates.
*
P-values are based on ANOVA comparing the three groups.
Note: NfL = neurofilament light
MMSE = Mini-Mental State Exam
CERAD = Consortium to Establish a Registry for Alzheimer’s Disease
Pg/ml= Picograms Per Milliliter