TABLE 3:
Baseline cerebral glucose metabolism in healthy controls (HC), PD subjects with (PD[+]D) and without (PD[−]D) incident dementia.1
| Region | PD[+]D (n=6) |
PD[−]D (n=17) |
HC (n=27) |
Age Effect |
Group Effect |
Overall Model |
|---|---|---|---|---|---|---|
| Primary Sensorimotor Cortex | 1.40 ± 0.10 n/a |
1.40 ± 0.11 n/a |
1.42 ± 0.12 n/a |
F=9.03; P=0.0043 | F=0.23; P=0.79 | F=3.74; P=0.017 |
| Parietal Association Cortex | 1.35 ± 0.19 n/a |
1.42 ± 0.15 n/a |
1.45 ± 0.12 n/a |
F=10.32; P=0.0024 | F=1.46; P=0.24 | F=6.64; P=0.0008 |
| Posterior Cingulate Cortex | 1.45 ± 0.14 A |
1.57 ± 0.18 B |
1.65 ± 0.12 B |
F=8.43; P=0.0057 | F=5.23; P=0.009 | F=9.37; P<0.0001 |
| Occipital Cortex | 1.35 ± 0.14 A |
1.44 ± 0.14 B |
1.53 ± 0.12 B |
F=11.52; P=0.0014 | F=7.02; P=0.0022 | F=12.03; P<0.0001 |
| Frontal Association Cortex | 1.43 ± 0.08 n/a |
1.45 ± 0.12 n/a |
1.50 ± 0.13 n/a |
F=13.87; P=0.0005 | F=1.46; P=0.25 | F=7.27; P=0.0004 |
| Anterior Cingulate Cortex | 1.34 ± 0.07 n/a |
1.35 ± 0.12 n/a |
1.39 ± 0.13 n/a |
F=27.71; P<0.0001 | F=1.49; P=0.24 | F=12.97; P<0.0001 |
| Temporal Association cortex | 1.24 ± 0.11 n/a |
1.28 ± 0.10 n/a |
1.30 ± 0.10 n/a |
F=6.46; P=0.015 | F=1.05; P=0.36 | F=4.25; P=0.0099 |
| Hippocampus | 1.05 ± 0.09 n/a |
1.08 ± 0.06 n/a |
1.10 ± 0.08 n/a |
F=6.18; P=0.017 | F=1.22 P=0.31 | F=4.25; P=0.001 |
| Amygdala | 1.01 ± 0.09 n/a |
1.05 ± 0.09 n/a |
1.04 ± 0.08 n/a |
F=1.72; P=0.20 | F=0.35; P=0.71 | F=1.28; P=0.30 |
| Thalamus | 1.54 ± 0.06 n/a |
1.47 ± 0.10 n/a |
1.54 ± 0.12 n/a |
F=0.65; P=0.43 | F=2.75; P=0.074 | F=1.93; P=0.14 |
| Caudate Nucleus | 1.42 ± 0.16 A |
1.47 ± 0.11 B |
1.55 ± 0.20 B |
F=11.46; P=0.0015 | F=3.24; P=0.048 | F=7.80; P=0.0003 |
| Putamen | 1.71 ± 0.13 n/a |
1.62 ± 0.13 n/a |
1.58±0.16 n/a |
F=0.65; P=0.43 | F=0.27; P=0.77 | F=0.28; P=0.83 |
Analysis of covariance F-values are presented with Duncan post-hoc testing between subgroups: sub-group means with the same letter are not significantly different. Brain regions are averaged for left and right hemispheres.
1
Data are presented as mean ± SD unless otherwise indicated.