TABLE 4:
Changes in regional cerebral glucose metabolism between baseline and 2-year follow-up imaging in the PD[+]D converters (within-subject analysis).1
| Region | PD[+]D Baseline (n=5) |
PD[+]D At 2 years (n=5) |
% Decline | t-value; Significance |
|---|---|---|---|---|
| Primary Sensorimotor Cortex | 1.37 ± 0.10 | 1.33 ± 0.13 | −3.0 ± 4.2% | t=−1.61; P=0.18 |
| Parietal Association Cortex | 1.31 ± 0.20 | 1.21 ± 0.17 | −7.1 ± 4.6% | t =−3.42; P=0.027 |
| Posterior Cingulate Cortex | 1.39 ± 0.16 | 1.26 ± 0.10 | −9.1 ± 5.5% | t =−3.73; P=0.02 |
| Occipital Cortex | 1.31 ± 0.15 | 1.21 ± 0.11 | −7.1 ± 2.3% | t =−6.89; P=0.0023 |
| Frontal Association Cortex | 1.38 ± 0.12 | 1.29 ± 0.13 | −6.7 ± 3.4% | t =−4.46; P=0.011 |
| Anterior Cingulate Cortex | 1.26 ± 0.08 | 1.20 ± 0.13 | −4.6 ± 5.1% | t =−2.04; P=0.11 |
| Temporal Association Cortex | 1.20 ± 0.12 | 1.14 ± 0.10 | −4.5 ± 1.8% | t =−5.53; P=0.0052 |
| Hippocampus | 1.02 ± 0.09 | 0.99 ± 0.10 | −3.4 ± 2.6% | t =−2.92; P=0.043 |
| Amygdala | 1.00 ± 0.10 | 0.97 ± 0.11 | −3.1 ± 3.9% | t =−1.76; P=0.15 |
| Thalamus | 1.52 ± 0.07 | 1.35 ± 0.11 | −11.4 ± 4.9% | t =−5.25; P=0.006 |
| Caudate Nucleus | 1.35 ± 0.18 | 1.18 ± 0.14 | −11.8 ± 9.6% | t =−2.73; P=0.056 |
| Putamen | 1.71 ± 0.12 | 1.57 ± 0.16 | −8.2 ± 7.7% | t =−2.17; P=0.076 |
Paired Student t values with levels of significance are presented.
1
Data are presented as mean ± SD, unless otherwise indicated.