Figure 1. Survival in PD in relation to baseline cNfL concentration.
(A) Box plots of baseline neurofilament light chain protein in CSF (cNfL) levels in Parkinson disease (PD). Cumulative survival for patients with a baseline cNfL below the median concentration of 903 ng/L (blue line) compared with those with cNfL above 903 ng/L (red line) in the (B) New Parkinsonism in Umeå (NYPUM) cohort and (C) validation cohort. (D) Cumulative survival in the combined, pooled cohort for patients (n = 293) with baseline cNfL levels in the lowest (<660 ng/L; blue line) and highest (>1,255 ng/L; green line) quartiles and those with concentrations between these levels (red line).