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Peripheral deletion of clone 4 T cells occurs independently of death ligands. Clone 4, lpr/lpr clone 4, TNFR1−/− clone 4, or TNFR2−/− clone 4 T cells were CFSE labeled and transferred into InsHA recipients. Eight days later, peripheral and pancreatic LNs were harvested and donor CFSE-labeled CD8 T cells were analyzed by flow cytometry. Data are representative of three to four mice per group from one of two independent experiments with similar results.
