Table 3.
Single- and double-strand break yields following aqueous plasmid irradiation with 100–200 MeV electrons at Conventional and FLASH dose rates, calculated using the McMahon32 fit.
Energy (MeV) | VHEE Dose rate | |||
---|---|---|---|---|
Conventional (~ 0.5 Gy s−1) | FLASH (> 108 Gy s−1) | |||
SSB (Mbp−1 Gy−1) | DSB(Mbp−1 Gy−1) | SSB (Mbp−1 Gy−1) | DSB (Mbp−1 Gy−1) | |
100 | 15.42 ± 0.86 | 0.35 ± 0.02 | 20.31 ± 1.20 | 0.37 ± 0.03 |
150 | 17.63 ± 0.57 | 0.35 ± 0.03 | 18.74 ± 0.52 | 0.37 ± 0.04 |
200 | 20.19 ± 0.56 | 0.38 ± 0.02 | 21.22 ± 0.38 | 0.38 ± 0.02 |
Standard error based on six agarose gel electrophoresis repeats for 200 MeV and five for 150 and 100 MeV.