. 2021 Feb 8;13:38. doi: 10.1186/s13195-020-00756-6

Table 4.

Cohort 2. Alzheimer’s disease (AD) group compared to non-AD group. p values and Akaike information criterion (AIC) from binary logistic regression models. Area under the curve (AUC), 95% confidence intervals (95% CI) and differences between AUCs measured with DeLong test from receiver operating characteristic (ROC) analysis. APOE stands for presence of at least one APOE ε4 allele

	Cohort 2	p	AIC	AUC	95%CI	p value for difference with model containing N-224 alone
AD vs. non-AD	N-224	< 0.0001	423.5	0.808	0.760–0.855	–
	Age	< 0.0001	451	0.702	0.646–0.758	0.002
	T-tau	< 0.0001	284	0.905	0.875–0.936	< 0.0001
	P-tau181	< 0.0001	228.6	0.938	0.910–0.966	< 0.0001
	N-224+T-tau	< 0.0001	316.2	0.905	0.875–0.936	< 0.0001
	N-224+P-tau181	< 0.0001	266.5	0.936	0.907–0.965	< 0.0001
	N-224+APOE	< 0.0001	419.6	0.829	0.787–0.870	ns
	Aβ42+P-tau181	< 0.0001	257.9	0.932	0.905–0.958	< 0.0001