Fig. 5. Relative increase in singletons and doubletons of the site frequency spectrum across McVicker’s B and the population size inferred from demographic inference using various sample sizes.
a, The relative increase in the singleton (left) and doubleton (right) bins of the site frequency spectrum for decreasing percentile bins of McVicker’s B compared with the highest percentile bin of B. The higher percentiles of B indicate weaker effects of selection at linked sites (SaLS). These relative increases are plotted for different sample sizes. b, Each point corresponds to the population size inferred in the last generation of an exponential growth model for Europeans. Demographic inference was conducted with different sample sizes for fourfold degenerate sites (n = 4,718,653 sites) and the highest 1% B sites (n = 10,977,437 sites). Error bars show 95% confidence intervals (see Supplementary Table 14 for parameter values). Ne, effective population size.