Figure 1.
MAIT Cell Identification. A representation of known biologically significant markers found on MAIT cells. Pictured is the Vα7.2 TCR, co-stimulatory molecules CD8(+/−), CD3, CD4(+/−), CD27, and CD28, coinhibitory and immunotherapy target molecule PD-1, cytokine receptors IL-1R, IL-7R, IL-12R, IL-15R, IL-18R (CD218), and IL-23R, chemokine receptors CCR5, CCR6, CCR9, CXCR6, activation markers HLA-DR, CD69, CD39, CD38, CD25, CD44, and degranulation marker CD107a (intracellular), and other identification markers CD161, MDR1, and CD26. Identification transcription factors include PLZF, Eomesodermin, RORγt, and T-Bet.