TABLE 5.
Dose proportionality of EIDD-1931 (50 to 800 mg molnupiravir, single ascending doses)
| Parametera | nb | Slope (90% confidence interval) | Between-subject geometric coefficient of variation | Lack of fit P value |
|---|---|---|---|---|
| AUCinf (ng · h/ml) | 36 | 1.07 (1.02–1.13) | 21.5 | 0.9724 |
| AUClast (ng · h/ml) | 36 | 1.09 (1.03–1.15) | 21.9 | 0.9750 |
| Cmax (ng/ml) | 36 | 1.01 (0.927–1.08) | 29.8 | 0.9996 |
a
AUCinf, area under the plasma concentration-time curve from time zero extrapolated to infinity; AUClast, area under the plasma concentration-time curve from time zero to the last measurable nonzero concentration; Cmax, maximum observed concentration.
b
n, number of observations.