Table 2.
Summary of mGluR, transporters, enzymes and glutamate immunostaining. Abbreviations: NC = normal control; GM = cortical gray matter; WM = white matter. Cells with the morphology: AS = astrocytes; AX = dystrophic axons; Mac = macrophages.
| Antibody and cells | mGluR1 | mGluR2/3 | mGluR5 | GLT‐1 | EAAC1 | GDH | GS | Glutamate | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AS | AX | AS | AS | AS | AS | Mac | AS | Mac | AS | Mac | AS | |
| NC GM | + | − | − | − | −/+‡ | ++* | − | − | − | − | − | − |
| NC WM | − | − | − | − | −/+‡ | ++ | − | − | − | − | − | − |
| Active plaque rim | + | −/+ | + | ++++ | ++++ | ++ | + | ++ | + | +++ | + | ++ |
| Active plaque | −/+† | −/+ | +† | ++++ | ++++ | ++ | + | ++ | + | +++ | + | ++ |
| Chronic plaque | −/+ | − | −/+ | ++++§ | ++++§ | +++§ | −/+ | −/+ | −/+ | −/+ | −/+ | −/+ |
The presence of immunoreactive cells is expressed as a range from − (no cells) to ++++ (high numbers of cells).
*
Perineuronal satellite glial cells.
†
Possible glial progenitor cells.
‡
Large cells with complex branching processes.
§
Dense astrocyte processes with few visible perikarya.