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. 2021 May 24;12:616967. doi: 10.3389/fimmu.2021.616967

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Copyright © 2021 Schubert, Karkossa, Schor, Engelmann, Steinheuer, Bruns, Rolle-Kampczyk, Hackermüller and von Bergen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proteomic profiling of MAIT cell activation. (A) Principle component analysis of the proteome of MAIT cells stimulated with IL-12/IL-18, a-CD3/a-CD28 or a combination of both. Each point represents a single donor (n=4). Overlap of (B) all detected proteins and (C) differentially abundant proteins in stimulated MAIT cells. (D) Volcano plots highlighting differentially abundant proteins in stimulated MAIT cells (p-value ≤ 0.05). (E) Heatmap of selected, significantly enriched pathways with a z-score reflecting up- or downregulation, determined by IPA (padj ≤ 0.5).