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. 2021 Jun 7;12:3400. doi: 10.1038/s41467-021-23620-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — The performance of plasma neurofilament light (NfL) concentration cutoffs to identify neurodegenerative disorders in >65 (A) and <65 (B). The KCL and Lund cohorts are combined for this analysis. AD Alzheimer’s disease, ALS amyotrophic lateral sclerosis, CBS corticobasal syndrome, DLB dementia with Lewy bodies, DS Down syndrome, DSAD Down syndrome Alzheimer’s disease, EOAD early-onset Alzheimer’s disease, FTD frontotemporal dementia. MCI mild cognitive impairment, MSA multiple system atrophy, PD Parkinson’s disease, PDD Parkinson’s disease dementia, PSP progressive supranuclear palsy, SCD subjective cognitive decline, VaD vascular dementia.