Table 1.
Demographics of the KCL cohort.
| Cognitively unimpaired | Cognitive impairment | Parkinsonian | Other | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Characteristics | CU Aβ− | CU Aβ+ | MCI Aβ− | MCI Aβ+ | EOAD | AD | FTD | PDD/DLB | PD | CBS/PSP | DS | DSAD | ALS | Depression | |
| Number | 805 | 130 | 28 | 55 | 31 | 59 | 102 | 54 | 59 | 140 | 19 | 29 | 12 | 50 | 37 |
| Age, years, mean (SD) | 63.6 (14.6) | 64.0 (14.1) | 66.3 (7.7) | 70.7 (6.36) | 69.6 (7.0) | 57.8 (5.2) | 76.1 (6.2) | 65.4 (9.5) | 77.5 (6.4) | 65.5 (10.0) | 70.4 (8.4) | 50.4 (11.4) | 59.1 (9.8) | 62.2 (12.5) | 32.3 (6.9) |
| Female, n (%) | 413 (48.5) | 63 (54.8) | 13 (46.4) | 29 (52.7) | 16 (51.6) | 32 (49.2) | 55 (53.9) | 23 (42.6) | 32 (54.2) | 52 (37.1) | 10 (52.6) | 10 (34.5) | 4 (33.3) | 13 (26.0) | 35 (68.6) |
| APOE e4 carriers, n (%) [missing] | 131 (35.1) [479] | 18 (28.1) [51] | 8 (30.8) [2] | 20 (38.5) [3] | 15 (50.0) [1] | 8 (34.8) [42] | 43 (47.3) [11] | 9 (25.0) [18] | 3 (25.0) [7] | 4 (14.8) [2] | 3 (25.0) | ||||
| MMSE, mean (SD) | 24.3 (5.8) | 29.4 (1.0) | 29.0 (1.0) | 26.0 (3.2) | 26.0 (2.2) | 22.2 (6.5) | 19.9 (6.7) | 25.9 (4.5) | 20.2 (4.2) | 27.3 (2.6) | 23.1 (5.3) | ||||
| UPDRS-III | 24.8 (10.9) [24] | 20.1 (2.3) | 17.8 (10.3) [22] | 36.5 (20.3) [2] | |||||||||||
| Hoehn & Yahr scale | 2.3 (0.7) [24] | 2.2 (0.5) | 1.9 (0.6) [22] | 2.8 (0.9) [2] | |||||||||||
| Diagnostic delay, months [missing] | 7.8 (6.9) [7] | 7.8 (6.9) [7] | |||||||||||||
| HAM-D | >13 = 15 >17 = 22 | ||||||||||||||
| CSF Aβ, mean (SD) | 675 (352) | 999 (317) | 405 (103) | 921 (385) | 413 (120) | 434 (155) | |||||||||
| Aβ PET | 1.55 (0.5) | 1.29 (0.1) | 1.81 (0.3) | 2.08 (0.4) | 1.22 (0.3) | 1.61 (0.2) | |||||||||