TABLE 2.
High-fat-fed PTP-1B−/− mice have reduced body fat storesa
| Genotype (n) | Mean carcass composition ± SEM
|
|||||
|---|---|---|---|---|---|---|
| BW (g) | Water (g) | Lipid
|
Fat-free dry mass
|
|||
| g | % BW | g | % BW | |||
| WT (7) | 40.57 ± 3.81a | 18.84 ± 1.12a | 8.43 ± 1.24a | 19.96 ± 1.40a | 13.30 ± 1.54a | 32.44 ± 0.94a |
| PTP-1B+/− (5) | 36.60 ± 3.14a | 18.24 ± 0.98a,b | 6.82 ± 1.38a | 17.72 ± 2.24a | 11.54 ± 0.93a | 31.74 ± 1.21a,b |
| PTP-1B−/− (9) | 25.33 ± 1.44b | 15.38 ± 0.81b | 2.40 ± 0.41b | 8.97 ± 1.34b | 7.56 ± 0.39b | 29.98 ± 0.37b |
a
Male PTP-1B−/−, PTP-1B+/−, and WT mice were fed a high-fat diet ad libitum for 16 weeks. Body weight (BW) and food intake were measured weekly. Mice were killed at 20 weeks of age, and total carcass fat (triglycerides), fat-free dry mass, and water content were determined. Values in the same column not sharing a superscript letter are significantly different (P < 0.05).