TABLE 2.
MIC distributions, antimicrobial susceptibilities, and spectra of activity of the different antimicrobial agents tested for the MRSA isolates testeda
Antimicrobial agent | No. of isolates for which MIC (mg/liter) is:
|
MIC50/MIC90b | % Susceptible | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<0.03 | 0.06 | ≤0.12 | 0.12 | 0.25 | ≤0.5 | 0.5 | 1 | 2 | >2 | ≤4 | 4 | >4 | 8 | >8 | |||
Erythromycin | 7 | 28 | 40 | 13 | 17 | 7 | 8 | 644 | >8/>8 | 4.8 | |||||||
Clindamycin | 103 | 60 | 5 | 4 | 1 | 2 | 7 | 572 | >8/>8 | 23.3 | |||||||
Gentamicin | 21 | 58 | 75 | 6 | 5 | 9 | 16 | 574 | >16/>16 | 22.8 | |||||||
Tetracycline | 309 | 11 | 444 | >8/>8 | 42.9 | ||||||||||||
Doxycycline | 300 | 5 | 22 | 150 | 287 | 4/8 | 85.2 | ||||||||||
Minocycline | 132 | 16 | 103 | 74 | 27 | 2/4 | 92.3 | ||||||||||
Ciprofloxacin | 1 | 9 | 16 | 23 | 9 | 12 | 9 | 605 | >2/>2 | 9.2 | |||||||
Gatifloxacinc | 18 | 23 | 19 | 5 | 11 | 79 | 376 | 233 | 2/4 | ||||||||
Trovafloxacinc | 43 | 14 | 7 | 9 | 97 | 255 | 195 | 144 | 1/>4 | ||||||||
Rifampin | 33 | 240 | 9 | 20 | 78 | 334 | 2/>2 | 46.1 | |||||||||
Chloramphenicol | 1 | 1 | 2 | 2 | 10 | 180 | 438 | 130 | 8/16 | 83.0 | |||||||
Quinupristin-dalfopristin | 24 | 167 | 427 | 111 | 14 | 3 | 12 | 6 | 0.5/1 | 99.5 | |||||||
Linezolidcd | 0 | 6 | 7 | 166 | 220 | 13 | 0 | 0 | 2/2 | ||||||||
Teicoplanin | 5 | 35 | 158 | 260 | 236 | 63 | 5 | 2 | 1/2 | 99.7 | |||||||
Vancomycin | 1 | 1 | 65 | 493 | 200 | 4 | 0 | 0 | 1/2 | 100 |
A total of 764 MRSA isolates were tested.
MIC50/MIC90, MICs at which 50%/90% of isolates are inhibited.
Investigational drug. No susceptibility breakpoints are available (10).
Only 412 MRSA isolates were tested, unless indicated otherwise.