Table 4.
Area under receiver operator characteristics curves
| AUC for milestone | S-NfLa | S-NfL + AaO | S-NfL + SCS + AaO | S-NfL + PIGD score + AaO |
| Walking-aid | 0.705 | 0.851 | 0.788 | 0.822 |
| (p = 0.035) | (p = 0.128) | (p = 0.033) | ||
| Nursing home | 0.699 | 0.821 | 0.814 | 0.805 |
| (p = 0.050) | (p = 0.0329) | (p = 0.049) | ||
| HY5 | 0.680 | 0.824 | 0.877 | 0.865 |
| (p = 0.027) | (p = 0.001) | (p = 0.003) | ||
| Dementia | 0.669 | 0.825 | 0.765 | 0.775 |
| (p = 0.014) | (p = 0.021) | (p = 0.005) | ||
| Death | 0.680 | 0.907 | 0.885 | 0.887 |
| (p = 0.000) | (p = 0.001) | (p = 0.001) |
Area under receiver operator characteristics (ROC) curves for having reached five different milestones of disease progression at any point during the study period. p values represent comparison to S-NfL AUC using Delong method. aAge adjusted S-NfL levels; AUC, area under ROC-curve; S-NfL, serum neurofilament light chain; S-NfL + AaO, combined model based on tertiles of age at onset and S-NfL levels; S-NfL + SCS + AaO, combined model based on simplified clinical subtype combined with tertiles of age at onset and S-NfL levels; S-NfL + PIGD score + AaO, combined model based on tertiles of postural instability and gait disorder score, age at onset, and S-NfL level.