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. Author manuscript; available in PMC: 2022 Apr 4.
Published in final edited form as: Parkinsonism Relat Disord. 2019 Jan 31;62:201–209. doi: 10.1016/j.parkreldis.2018.12.025

Table 1.

LP-related adverse events at baseline by group.

Adverse Event Group
PD Subjects Healthy Controls SWEDD Subjects RR (95% CI)

(N = 421) (N = 196) (N = 62)

# of Subjects % of Subjects # of Events Rate # of Subjects % of Subjects # of Events Rate # of Subjects % of Subjects # of Events Rate PD vs. HC PD vs. SWEDD
Total 85 20.2% 100 0.238 51 26.0% 59 0.301 17 27.4% 21 0.339 0.78 (0.58, 1.06) 0.74 (0.47, 1.16)
Most Common
 Post-LP Headache 49 11.6% 49 0.116 28 14.3% 28 0.143 12 19.4% 12 0.194 0.81 (0.53, 1.25) 0.60 (0.34, 1.06)
 Post-LP Back Pain 22 5.2% 23 0.055 15 7.7% 15 0.077 7 11.3% 7 0.113 0.68 (0.36, 1.28) 0.46 (0.21, 1.03)
Ear
 Tinnitus 1 0.2% 1 0.002 0 0.0% 0 0.000 0 0.0% 0 0.000 . .
Gastrointestinal
 Abdominal pain 0 0.0% 0 0.000 1 0.5% 1 0.005 0 0.0% 0 0.000 . .
 Nausea 4 1.0% 4 0.010 1 0.5% 1 0.005 0 0.0% 0 0.000 1.86 (0.21, 16.53) .
 Vomiting 1 0.2% 1 0.002 0 0.0% 0 0.000 0 0.0% 0 0.000 . .
General
 Fatigue 1 0.2% 1 0.002 1 0.5% 1 0.005 0 0.0% 0 0.000 0.47 (0.03, 7.48) .
 Pain 1 0.2% 1 0.002 0 0.0% 0 0.000 0 0.0% 0 0.000 . .
Musculoskeletal
 Musculoskeletal pain 0 0.0% 0 0.000 1 0.5% 1 0.005 0 0.0% 0 0.000 . .
 Musculoskeletal stiffness 2 0.5% 2 0.005 1 0.5% 1 0.005 0 0.0% 0 0.000 0.93 (0.08, 10.20) .
 Pain in extremity 1 0.2% 1 0.002 0 0.0% 0 0.000 0 0.0% 0 0.000 . .
 Post-LP Back Pain 22 5.2% 23 0.055 15 7.7% 15 0.077 7 11.3% 7 0.113 0.68 (0.36, 1.28) 0.46 (0.21, 1.03)
 Post-LP Injection Site Pain 4 1.0% 4 0.010 1 0.5% 1 0.005 2 3.2% 2 0.032 1.86 (0.21, 16.53) 0.29 (0.05, 1.55)
Nervous System
 Dizziness 3 0.7% 3 0.007 2 1.0% 2 0.010 0 0.0% 0 0.000 0.70 (0.12, 4.16) .
 Intracranial hypotension 0 0.0% 0 0.000 1 0.5% 1 0.005 0 0.0% 0 0.000 . .
 Loss of consciousness 1 0.2% 1 0.002 0 0.0% 0 0.000 0 0.0% 0 0.000 . .
 Migraine 1 0.2% 1 0.002 0 0.0% 0 0.000 0 0.0% 0 0.000 . .
 Paraesthesia 0 0.0% 0 0.000 1 0.5% 1 0.005 0 0.0% 0 0.000 . .
 Parkinson’s disease 1 0.2% 1 0.002 0 0.0% 0 0.000 0 0.0% 0 0.000 . .
 Post-LP Headache 49 11.6% 49 0.116 28 14.3% 28 0.143 12 19.4% 12 0.194 0.81 (0.53, 1.25) 0.60 (0.34, 1.06)
 Presyncope 0 0.0% 0 0.000 1 0.5% 1 0.005 0 0.0% 0 0.000 . .
 Radicular pain 2 0.5% 2 0.005 0 0.0% 0 0.000 0 0.0% 0 0.000 . .
 Syncope 1 0.2% 1 0.002 0 0.0% 0 0.000 0 0.0% 0 0.000 . .
Procedural Related Injuries
 Contusion 1 0.2% 1 0.002 0 0.0% 0 0.000 0 0.0% 0 0.000 . .
 Post-LP Injection Site Pain 3 0.7% 3 0.007 5 2.6% 5 0.026 0 0.0% 0 0.000 0.28 (0.07, 1.16) .

Column definitions.

# of Subjects: Number of subjects who had AE.

% of Subjects: Percentage of subjects who had AE.

# of Events: Total number of AEs; includes multiple AEs of same type per subject.

Rate: Number of AEs per total number of subjects.

RR(95% CI): Relative Risk and 95% Confidence Interval for comparing percentages of subjects who had AE in PD subjects vs. healthy controls or PD subjects vs. SWEDD subjects.