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. 2022 Mar 28;12:749579. doi: 10.3389/fneur.2021.749579

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Copyright © 2022 Pavel, Henderson and DeBruin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ictal and Interictal SPECT (A–C) Example of SPECT scan studies cited in TTASAAN report. Perfusion tracer is iodinated N,N,N'-trimethyl-N'-(2-hydroxy-3– methyl-5-iodobenzyl)-1,3-propane-diamine (HIPDM). Anatomical details are lacking [The figure was originally published in JNM. © SNMMI (149)]. (D,E) Modern 2021 HMPAO SPECT perfusion scans for seizure localization. (D) Ictal scan. (E) Interictal scan. (F) SISCOM image wherein interictal scan data is subtracted from ictal scan data and the resulting data is overlayed on an anatomical MRI. Images courtesy of– Leonard Numerow MD FRCP(C), Radiology and Nuclear Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.