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. 2022 Oct 17;12(10):1727. doi: 10.3390/jpm12101727

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Metabolite-metabolite interaction network for significant metabolites that differentiate participants with (A) autism spectrum disorder (ASD) from typically developing controls and (B) those with ASD with and without neurodevelopmental regression (NDR). Size of the node indicates importance in the network. The network highlights that importance of adenosine triphosphate in differentiating those with and without ASD and those with ASD but with and without NDR. The importance of nicotinamide metabolism in differentiating those with and without NDR is also highlighted by the interaction analysis.

Metabolite-metabolite interaction network for significant metabolites that differentiate participants with (A) autism spectrum disorder (ASD) from typically developing controls and (B) those with ASD with and without neurodevelopmental regression (NDR). Size of the node indicates importance in the network. The network highlights that importance of adenosine triphosphate in differentiating those with and without ASD and those with ASD but with and without NDR. The importance of nicotinamide metabolism in differentiating those with and without NDR is also highlighted by the interaction analysis.