Figure 2.
Metabolite-metabolite interaction network for significant metabolites that differentiate participants with (A) autism spectrum disorder (ASD) from typically developing controls. Size of the node indicates importance in the network. There were multiple metabolites that appeared to differential the individuals with ASD without a history of neurodevelopmental regression (NDR) from control (B), particularly phenylpyruvic acid, a phenylalanine derivative. Controls were differentiated from those with ASD and a history of NDR by several metabolites, particularly adenosine triphosphate.