Table 3.
Metabolites and their pathways which are different between autism spectrum disorder without neurodevelopmental regression as compared to control participants.
| Significant Metabolites | Significant Pathways | |||
|---|---|---|---|---|
| Metabolite | Fold ∆ | Pathway | Matched Metabolites | Impact |
| 5-Aminolevulinic acid *** | 0.15 | Phenylalanine, tyrosine and tryptophan metabolism * | Phenylpyruvic acid * | 0.00 |
| Cytidine *** | 6.12 | |||
| 4-Hydroxyproline ** | 0.17 | |||
| 4-Pyridoxic acid ** | 4.50 | |||
| 2,3,4,5-Tetrahydroxypentanoic acid ** | 4.31 | |||
| D-Leucic acid * | 0.26 | |||
| L-3-Phenyllactic acid * | 0.27 | |||
| Ribitol * | 3.66 | |||
| Isobutyric acid * | 3.49 | |||
| Xylitol * | 3.48 | |||
| 4-Hydroxybenzaldehyde * | 0.29 | |||
| Taurine * | 3.27 | |||
| 1-Methylhistamine * | 3.23 | |||
| 2-Aminoisobutyric acid * | 3.22 | |||
| 4-Hydroxybutyric acid * | 0.31 | |||
| Capric acid * | 0.32 | |||
| Phenylpyruvic acid * | 0.33 | |||
| Dodecanoic acid * | 0.33 | |||
* p ≤ 0.05, ** p ≤ 0.01; *** p ≤ 0.001.