. 2022 Oct 17;12(10):1727. doi: 10.3390/jpm12101727

Table 4.

Metabolites and their pathways which are different between autism spectrum disorder with neurodevelopmental regression and control participants.

Significant Metabolites		Significant Pathways
Metabolite	Fold ∆	Pathway	Matched Metabolites	Impact
Cytidine ***	9.66	Aminoacyl-tRNA biosynthesis ***	L-Asparagine , L-Histidine , Glycine , L-Serine	0.17
Taurine ***	7.54	Aminoacyl-tRNA biosynthesis ***	L-Asparagine , L-Histidine , Glycine , L-Serine	0.17
Adenosine triphosphate ***	6.86	Histidine metabolism **	L-Histidine, 1-Methylhistamine	0.31
Glycine **	6.49	Glyoxylate and dicarboxylate metabolism *	L-Serine , Glycine	0.15
Dodecanoic acid **	0.20	Glycine, serine and threonine metabolism *	L-Serine , Glycine	0.46
D,L-Acetyl-carnitine **	4.84
Dihydroxyacetone **	4.76
Acetamide **	4.69
L-Histidine **	4.60
Hydroxykynurenine **	4.54
L-Serine **	4.49
1-Methylhistamine *	4.16
L-Asparagine *	3.94
trans-Aconitic acid *	0.28
2,3,4,5-Tetrahydroxypentanoic acid *	3.49
Capric acid *	0.30
Heptadecanoic acid *	3.33
2-Aminoisobutyric acid *	3.31
Isobutyric acid *	3.27

* p ≤ 0.05, ** p ≤ 0.01; *** p ≤ 0.001.