. 2022 Oct 17;12(10):1727. doi: 10.3390/jpm12101727

Table 6.

Metabolites and their pathways which correlate with neurodevelopment.

Significant Metabolites		Significant Pathways
Metabolite	r	Pathway	Matched Metabolites	Impact
Phenylpyruvic acid **	0.35	Glyoxylate and dicarboxylate metabolism ***	Citrate ,* L-Serine , Glycine , Isocitrate ,* L-Glutamine *	0.18
Cytidine **	−0.35	Glyoxylate and dicarboxylate metabolism ***		0.18
Glycine **	−0.33	Glycine, serine and threonine metabolism *	L-Serine , Glycine , 5-Aminolevulinate	0.46
Taurine **	−0.33	Glycine, serine and threonine metabolism *	L-Serine , Glycine , 5-Aminolevulinate	0.46
Phenylbutazone **	−0.32	Citrate cycle (TCA Cycle) *	Isocitrate , Citrate	0.14
Amiloride **	−0.31	Aminoacyl-tRNA biosynthesis *	L-Glutamine , Glycine *, L-Serine **	0.17
Glucuronic acid **	0.31	Aminoacyl-tRNA biosynthesis *	L-Glutamine , Glycine *, L-Serine **	0.17
L-Serine **	−0.30
3S-methyl-2-oxo-pentanoic acid **	0.30
DL-Acetylcarnitine **	−0.30
1-Methylhistamine **	−0.30
L-3-Phenyllactic acid **	0.29
Dihydroxyacetone *	−0.29
L-Glutamine *	−0.28
Dodecanoic acid *	0.27
Citraconic acid *	0.27
Isocitric acid *	0.27
4-Pyridoxic acid *	−0.26
Capric acid *	0.26
Ketoleucine *	0.26
Pregnenolone sulfate *	−0.26
5-Aminolevulinic acid *	0.25
Isovaleric acid *	−0.25
2-Aminoisobutyric acid *	−0.24
Citric acid *	0.24
4-Hydroxyproline *	0.24
D-Leucic acid *	0.23
D-Ribose 5-phosphate *	−0.22

* p ≤ 0.05, ** p ≤ 0.01; *** p ≤ 0.001.