. 2022 Oct 17;12(10):1727. doi: 10.3390/jpm12101727

Table 10.

Metabolites and their pathways which correlate with methylation potential.

Significant Metabolites		Significant Pathways
Metabolite	r	Pathway	Matched Metabolites	Impact
Methylguanidine ***	0.41	Aminoacyl-tRNA biosynthesis ***	L-Asparagine , L-Histidine , L-Phenylalanine , L-Arginine , L-Glutamine , L-Serine , L-Methionine , L-Valine ,* L-Lysine , L-Isoleucine ,* L-Threonine *, L-Proline	0.17
L-Threonine ***	0.41
L-Homoserine ***	0.41
L-Lysine ***	0.36
L-Isoleucine **	0.33
L-Arginine **	0.31
Caprylic acid **	0.29	Valine, leucine and isoleucine biosynthesis ***	L-Threonine , L-Isoleucine , L-Valine *	0
Adenosine triphosphate **	0.29	Valine, leucine and isoleucine biosynthesis ***	L-Threonine , L-Isoleucine , L-Valine *	0
L-Methionine **	0.29	Cysteine and methionine metabolism *	L-Serine , L-Methionine *, (S)-2-Aminobutanoate*	0.17
Indolelactic acid **	0.29	Cysteine and methionine metabolism *	L-Serine , L-Methionine *, (S)-2-Aminobutanoate*	0.17
2-hydroxyglutaric acid **	0.28	Arginine biosynthesis *	L-Arginine **, L-Glutamine	0.08
L-Proline **	0.27	Nicotinate and nicotinamide metabolism *	Quinolinate , Nicotinamide	0.19
L-Phenylalanine **	0.27	Histidine metabolism *	L-Histidine ,* N(pi)-Methyl-L-histidine *	0.22
L-Alloisoleucine **	0.27	Histidine metabolism *	L-Histidine ,* N(pi)-Methyl-L-histidine *	0.22
L-Kynurenine *	0.26
L-Asparagine *	0.26
L-Alpha-aminobutyric acid *	0.26
1-Methylhistidine *	0.25
5-Hydroxyindoleacetic acid *	0.25
Quinolinic acid *	0.25
L-Valine *	0.24
L-Glutamine *	0.24
L-Serine *	0.23
L-Histidine *	0.22
Capric acid *	0.22
Niacinamide *	0.21
L-3-Phenyllactic acid *	0.21
Picolinic acid *	0.20

* p ≤ 0.05, ** p ≤ 0.01; *** p ≤ 0.001.