. 2022 Oct 17;12(10):1727. doi: 10.3390/jpm12101727

Table 15.

Metabolites and their pathways which correlate with a marker of inflammation.

Significant Metabolites		Significant Pathways
Metabolite	r	Pathway	Matched Metabolites	Impact
L-Glutamine ***	0.47	Aminoacyl-tRNA biosynthesis***	L-Asparagine , L-Histidine , L-Glutamine , Glycine ,* L-Serine **, L-Valine , L-Lysine , L-Tyrosine , L-Proline **	0.17
L-Serine ***	0.42
L-Proline ***	0.39
L-Histidine ***	0.39
DL-Acetylcarnitine ***	0.38	Glyoxylate and dicarboxylate metabolism*	L-Serine , Glycine ,* L-Glutamine ***	0.15
Palmitic acid ***	0.37	Glyoxylate and dicarboxylate metabolism*	L-Serine , Glycine ,* L-Glutamine ***	0.15
Acetamide ***	0.37	Glycine, serine and threonine metabolism*	L-Serine , Glycine ,* 5-Aminolevulinate *	0.46
L-Asparagine ***	0.34	Glycine, serine and threonine metabolism*	L-Serine , Glycine ,* 5-Aminolevulinate *	0.46
Stearic acid **	0.33	Histidine metabolism*	L-Histidine *, Imidazole-4-acetate *	0.22
D-Leucic acid **	−0.33	Histidine metabolism*	L-Histidine *, Imidazole-4-acetate *	0.22
Epinephrine **	0.32
Taurine **	0.30
6-Methyl-DL-Tryptophan **	0.29
Cytidine **	0.28
3-Hexenedioic acid **	−0.27
5-Hydroxyindoleacetic acid **	0.27
L-Tyrosine **	0.27
Glycine **	0.27
Adenosine triphosphate **	0.27
Imidazoleacetic acid *	0.26
Dihydroxyacetone *	0.26
Isobutyric acid *	0.25
Cytosine *	0.23
L-Alloisoleucine *	0.23
5-Aminolevulinic acid *	−0.23
Methylmalonic acid *	−0.22
Picolinic acid *	0.22
2-hydroxyglutaric acid *	0.22
L-Valine *	0.21
L-Lysine *	0.21
N-Acetylglutamine *	0.21

* p ≤ 0.05, ** p ≤ 0.01; *** p ≤ 0.001.