TABLE 1.
Comparison of i.d. LD50 of LVS in BKO and normal micea
| Expt | No. of mice/group (total no.) | i.d. LD50 of LVS for:
|
|
|---|---|---|---|
| Normal C57BL/6J mice | BKO mice | ||
| 1 | 5 (42) | 1.8 × 107 | 4.4 × 106 |
| 2 | 4 (33) | 2.3 × 107 | 7.3 × 106 |
a
The i.d. LD50 values calculated from deaths of mice given doses of LVS i.d. ranging from 105 to 108 are shown; actual LVS doses were confirmed by plate count at the time of inoculation. Mice were observed for morbidity and mortality through day 30, at which time surviving mice were sacrificed to assess clearance of bacteria from spleens.