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. 2022 Dec 13;8(12):e12193. doi: 10.1016/j.heliyon.2022.e12193

Table 7.

Polymer based nanomaterial in skin tissue engineering application.

Scaffold type Application Reference
GO in ASC derived ECM that crosslinked with Ginipin Scaffold for skin tissue engineering (Nyambat et al., 2018)
PCL/PU composite with GO Scaffold for human fibroblast cell (Sadeghianmaryan et al., 2020)
PU/Pluronic F127 Nanofibers containing peppermint extract loaded gelatin nanoparticles Scaffold for diabetic wounds healing (Almasian et al., 2021)
Collagen-coated nano-electrospun PCL Scaffold for attachment and proliferation of human endometrial stem cells (hEnSCs) on the composite (Sharif et al., 2018)
TEMPO-oxidized cellulose nanofiber-silk fibroin overexpression of wound healing markers (Shefa et al., 2017)
Chitosan-based nano-scaffolds Scaffold for antileishmanial wound dressing in BALB/c mice (Seyyed Tabaei, Rahimi et al., 2020)
Gelatin/poly-3-hydroxybutyrate nano/microfibers Scaffold for diabetic ulcer dressing (Sanhueza et al., 2021)
Silicon dioxide- PVP Scaffold for wound contraction and reepithelialization (Öri et al., 2017)
Chitosan hydrogel with silica nanoparticle Scaffold for regeneration of injured skin (Zhu et al., 2017)
Collagen hydrogel and silica core-shell nanoparticle Scaffold for sustain release of gentamicin and rifampin to prevent skin ulcers dressing contamination (Mebert et al., 2018)
Alginate hydrogel/nano zinc oxide composite Scaffold for for infected wounds (Mohandas et al., 2015)
Keratin-chitosan/n-ZnO nanocomposite hydrogel Scaffold to accelerate of wound treatment (Zhai et al., 2018)
chitosan and TiO2 Scaffold for skin tumor cure and regeneration of skin tissue (Wang et al., 2019)
Nano-cerium dioxide and MSC Scaffold for wound healing (Silina et al., 2021)
Molybdenum oxide-PCL nanofiber Scaffold to reduce viability of cancer cells and cancer progression (Janani et al., 2018)
Gold nanoparticles loaded into PEG and cationic PAH Scaffold for wound healing in animal model (Mahmoud et al., 2019)
nano-silver hydrogel coating film Scaffold for burned animal model (Xi et al., 2018)
GG-g-PAGA hydrogel and AgNPs Scaffold for wound dressing (Palem et al., 2019)
PVA/PEG/Chitosan Hydrogels with AgNPs Scaffold to increase bacteriostatic and cell viability rate (Li et al., 2019)
Hydrogel contained AgNPs obtained from brazilian pepper extracts Antimicrobial effect and excellent L929 fibroblast cells viability (de Oliveira et al., 2021)
Collagen-capped AgNPs and melatonin
PCL-Gt electrosun scaffold
Scaffold to accelerate skin tissue regeneration
Biocompatible with improved angiogenic
Property
(Ragothaman et al., 2021)
(Fabin Cheng et al., 2022)

Graphene oxide: GO; Adipose stem cell: ASC; Polycaprolactone: PCL; Polyurethane: PU; Polyvinylpyrrolidone: PVP; Mesenchymal stem cells: MSC; poly allyl amine hydrochloride:PAH; poly ethylene glycol:PEG; Guar gum-grafted-polyacrylamidoglycolic acid:GG-g-PAGA; Polyvinyl alcohol: PVA; Polyethylene glycol: PEG; Silver nanoparticles: AgNPs.