Table 2.
(a) Average (mean ± SD) distribution volume ratio (DVR) values representing [11C]TMSX binding to adenosine A2A receptors in whole, ipsilateral (ipsi) and contralateral (contra; relative to the clinically more affected side) striatal structures of healthy control (HC), Parkinson’s disease early stage (PDE) and Parkinson’s disease moderate-stage (PDM) groups, (b) Within and between-group comparison of ipsilateral and contralateral striatal structures reported with (without) Bonferroni correction
| Caudate | Putamen | Pallidum | |
|---|---|---|---|
| (a) | |||
| HC (avg left + right), mean ± SD | 1.163 ± 0.063 | 1.435 ± 0.030 | 1.135 ± 0.059 |
| PDE (avg left + right), mean ± SD | 1.056 ± 0.056 | 1.411 ± 0.080 | 1.217 ± 0.139 |
| PDE ipsi, mean ± SD | 1.054 ± 0.061 | 1.421 ± 0.067 | 1.234 ± 0.169 |
| PDE contra, mean ± SD | 1.080 ± 0.061 | 1.400 ± 0.125 | 1.193 ± 0.122 |
| PDM (avg left + right), mean ± SD | 1.146 ± 0.093 | 1.472 ± 0.071 | 1.231 ± 0.058 |
| PDM ipsi, mean ± SD | 1.151 ± 0.100 | 1.454 ± 0.075 | 1.239 ± 0.059 |
| PDM contra, mean ± SD | 1.147 ± 0.094 | 1.496 ± 0.091 | 1.223 ± 0.086 |
| (b) | |||
| HC left vs right, (P) | > 0.99 (0.77) | > 0.99 (0.62) | > 0.99 (0.59) |
| PDE ipsi vs HC, (P) | 0.01 (0.005) | > 0.99 (0.64) | 0.57 (0.18) |
| PDE contra vs HC, (P) | 0.06 (0.02) | > 0.99 ((0.52) | > 0.87 (0.29) |
| PDE ipsi vs contra, (P) | > 0.99 (0.39) | > 0.99 (0.66) | > 0.99 (0.56) |
| PDM ipsi vs HC, (P) | > 0.99 (0.50) | > 0.99 (0.59) | 0.02 (0.006) |
| PDM contra vs HC, (P) | > 0.99 (0.52) | 0.92 (0.31) | 0.92 (0.06) |
| PDM ipsi vs contra, (P) | > 0.99 (0.92) | 0.93 (0.30) | > 0.99 (0.66) |
P < 0.05 was considered statistically significant
Independent t-test was used for statistical comparison