TABLE 3.
Proportion of variance in QT interval duration explained by covariates and estimates of heritability in the European-American sample with and without each SNP individually under an additive genetic model
Covariates | Proportion of variance attributable to covariates | Proportion of variance attributable to each SNP | h 2 r |
---|---|---|---|
All European Americans | |||
RR interval, age, sex, diabetes, and BMI | 0.631 | 0.476 ± 0.14 | |
Covariates plus rs10494366 | 0.643 | 0.012 | 0.468 ± 0.14 |
Covariates plus rs10918594 | 0.651 | 0.020 | 0.418 ± 0.14 |
Diabetic European Americans only | |||
RR interval, age, sex, and BMI | 0.624 | 0.323 ± 0.18 | |
Covariates plus rs10494366 | 0.639 | 0.0152 | 0.294 ± 0.18 |
Covariates plus rs10918594 | 0.646 | 0.022 | 0.266 ± 0.17 |
h2r data are means SE. h2r represents the residual heritibility after adjusting for covariates and each SNP individually.