Table II.
Neurological and developmental characteristics
| Subject | Sex | Age at Ascertainment |
Autism Spectrum Disorder |
Cognitive- Developmental Findings |
Language Delay |
Motor Involvement |
History of Seizures/ EEG Results |
MRI- brain |
Behavioral Features |
|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 16 y | No | MR; SB5: FSIQ 44; VIQ 44; NVIQ 48; (CA 14 y) |
Expressive & receptive |
Walked at 18 months |
History of seizures; Abnormal EEG |
Normal | Inattention, impulsivity, hyperactivity |
| 2 | M | 2 y | Autism suspected, no formal evaluation available |
Global developmental delays |
Expressive & receptive |
Not documented | Not documented |
Not documented |
Not documented |
| 3 | F | 10 mo | Not suspected | Not evaluated | No | Mild gross motor delay, hypotonia |
None | None | Not documented |
| 4 | M | 4 yr | PDD-NOS (ADOS) | WPPSI-III VIQ 77, PIQ 98 (CA 4 y) |
Expressive | Hypotonia | EEG Normal | None | Attention concerns |
| 5 | F | 6 yr | No | Normal | 6 month receptive delay |
Normal | Not documented |
Not documented |
Not documented |
| 6 | F | 7 yr | PDD-NOS (ADOS) | Bayley II Mental Scale 91, 29 mo (CA 31 mo) |
Expressive | Motor coordination disorder |
None | None | Not documented |
| 7 | M | 14 yr | Autism (ADOS) | MR: SB5: FSIQ 47; VIQ 46; NVIQ 53 |
Expressive & receptive |
Normal | EEG Normal | None | Hyperactivity |
| 8 | F | 11 yr | No | MR: WISC-IV: VCI 67, PRI 63, WMI 59, PSI 75, FSIQ 58 (CA 11 y) |
Expressive & receptive |
Normal | None | Normal | Inattention, fidgety, disorganized |
| 9 | F | 4 yr | No | Normal | Expressive & receptive |
Hypotonia | None | Normal | Impulsivity and inattention |
| 10 | M | 2 yr | PDD-NOS (ADOS) | Normal | Expressive & receptive |
Normal | Not documented |
Not documented |
Not documented |
| 11 | M | 8 yr | No | Normal | No | Proximal and distal weakness, hypotonia |
None | None | Not documented |
| 12 | F | 19 mo | Not documented | Not documented | Not documented |
Normal | None | None | Not documented |
ADOS: Autism Diagnostic Observation Schedule; Bayley III: Bayley Scales of Infant and Toddler Development, Third Edition; BEAM: Brain Electrical Activity Mapping (quantitative EEG); CA: Chronological age at testing; MR: Mental Retardation; SB5: Stanford-Binet Intelligence Scales, Fifth Edition; FSIQ: full scale IQ; VIQ: Verbal IQ; PIQ: Performance IQ; WPPSI-III: Wechsler Preschool and Primary Scale of Intelligence, Third Edition; WISC-IV: Wechsler Intelligence Scale for Children, Fourth Edition; VCI: Verbal Comprehension Index, PRI: Perceptual Reasoning Index; WMI: Working Memory Index; PSI: Processing Speed Index.