Table 1. Demographic information of all samples.
Mean and standard deviation (in parenthesis) are provided, span, if helpful
| Derivation sample | Validation sample | |||
|---|---|---|---|---|
| Sample characteristic | ADNI NC | ADNI AD | BAC NC | UCSF AD |
| A. Demographics | ||||
| N subjects | 39 | 50 | 72 | 19 |
| Age at MRI, y | 78.0 (6.4), 62 – 94 | 76.5 (7.4), 59 – 88 | 74.9 (5.7), 63 – 88 | 67.8 (9.7)#, 58 – 89 |
| N women | 17 (44%) | 20 (40%) | 48 (67%) | 9 (47%) |
| Education, y | 15.8 (2.8), 9 – 20 | 14.6 (3.1)♮, 6 – 20 | 17.0 (1.9), 12 – 20 | 16.4(3.2), 9 – 22 |
| B. Measurements | ||||
| Δtime (MRI – FDG), y | 0.1 (0.1) | 0.1 (0.1) | 0.2 (0.4) | 0.4 (0.5) |
| Δtime (FDG – Aβ) | Florbetapir, y: 3.1 (2.1) CSF Aβ, d: 23.2 (35.6) |
n.a. | PIB, d: 0.0 (0.0) | n.a. |
| Δtime (NTS – MRI), y | 0.1 (0.1) | 0.1 (0.0) | 0.3 (0.2) | 0.3 (0.4) |
| C. Biomarkers | ||||
| N of Aβ-negative (−) or Aβ-positive (+) |
29 Florbetapir-, 10 CSF Aβ- |
n.a. | 47 PIB−, 25 PIB+ |
n.a. |
| APOE ε4 carrier | 6 (15%) | 36 (72%) | 22 (31%) | 10 (53%), missing: 3 |
| D. Clinical cognitive status | ||||
| MMSE | 29.2 (1.2) | 23.4 (2.2)* | 28.8 (1.4) | 20.3 (6.6)# |
| CDR (if available) 0/0.5/1/3 | 39/0/0 | 0/16/34 | n.a. | 1/5/10/1, missing: 2 |
Selected abbreviations: N - number, y - year, d - day, NTS - Neuropsychological Test Session, Δ - Difference, MMSE - Mini Mental Status Examination, CDR - Clinical Rating Scale, n.a. - not available
*
p < 0.05,
♮
p < 0.1 comparison between ADNI NC and ADNI AD,
#
p < 0.05, comparison between BAC NC and UCSF AD